Many scientists consider embryonic stem cells to be ideal
to treat disease because they multiply extensively and can
differentiate into all the cells and tissues of the body.
However, to obtain them, five-day-old embryos have to be
destroyed.
To avoid the ethical and political hurdles that surround
stem cells taken from embryos, scientists are hunting for
alternative sources.
Adult bone marrow
One promising source of stems cells might be from the bone
marrow of an adult. Stem cells from adult bone marrow normally
produce blood and bone marrow cells.
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Until recently, scientists thought it impossible
that these bone marrow cells could 'go back in time'
and re-invent themselves to produce completely different
cell types such as brain, nerve, gut or skin.
However, scientists in the United States have recently
identified a stem cell from adult bone marrow that they
believe can grow into any other cell type. "It's
an extraordinary thing," says stem-cell expert
Austin Smith of the Centre for Genome Research in Edinburgh,
UK.
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Not only would stem cells taken from a consenting adult be
ethically acceptable to most people and governments, they
would also be better for patients. Imagine you had a disease
killing your brain cells. Stem cells could be taken from your
bone marrow, manipulated in the laboratory so that they become
brain cells, and implanted back into your brain - hence no
rejection of the transplant by your immune system.
This is a fantastically exciting prospect - if it works.
Early results look promising, but scientists don't know
how versatile stem cells from bone marrow really are. They
are far more confident of what stem cells from embryos can
do.
Ultimately, different stem cell types might best treat
different diseases, so most scientists would opt for continued
research on both types.
Placental blood
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A final option for
a source of stem cells is umbilical cord blood - usually
discarded at birth. For some time now, mothers have been
able to donate the stem cells within their babys
umbilical cord to public cord blood banks.
Cord blood collected in this way has been used to successfully
treat leukaemia and immune disorders in unrelated patients.
Now companies have begun offering
a service to collect and store a mothers placental
blood for a fee. This blood could be used to treat the
baby if it were ever ill.
The companies claim that in the
future, cord blood could provide a source of stem cells
to cure stroke, heart disease, diabetes, Parkinson's
disease and Muscular
Dystrophy. In addition, at
the moment these stem cells could be used to treat blood
disorders such as leukaemia.
This procedure raises issues
such as, perhaps only the rich will be able to store
their cells, and that in some disorders the cord stem
cells will also be affected and therefore no good to
transplant.
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The beauty of collecting these stem cells is that they
are taken without affecting the mother or child. They are
also 100% compatible with the baby should he or she ever
develop an illness and be in need of stem cells.
These companies argue that in addition, the cord blood
from the baby might provide a source of compatible stem
cells for the baby's relations - brothers and sisters, parents
and grandparents.
For a few thousand dollars - could you afford not to store
them?
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